Superior Cell Analysis
Flow Cytometry has evolved. But cell controls have not.
Unlock new possibilities with Synthetic Cells.
Embrace the future of flow cytometry with our advanced solutions, designed with precision and your needs in mind.
Veronica Nash, PhD, US Regional Head of Flow Cytometry at Cerba Research“We’ve integrated Slingshot cell mimics as crucial controls in several of our flow cytometry workflows. Whether in assessing cell viability or managing compensation and unmixing, these off-the-shelf controls seamlessly slot into our processes. This enhances our workflow efficiency without having to compromise on data quality and reliability.”
Shortcomings of Current Methods
In flow cytometry, controls have traditionally come from blood specimens or solid-core plastic beads.
It’s time for a change. Current approaches to assay controls and reference materials rely on biobanks, odd blood blends using human and animal cells, or sourcing primary cells from active donors. And only <1% of blood diseases have available controls.
Current options fall well short for what you need.
Biological Controls
- Difficult to source the right reference materials
- High donor-to-donor variability
- Laborious cell line maintenance
- Poor shelf-life stability
Polystyrene solid-core beads
- Different properties from cells including refractive index and light scattering
- Mismatch of fluorescence especially for spectral flow cytometry
- Highly charged with high non-specific binding
Ground Breaking Approach
Ideal cellular mimics for calibration and standardization to ensure instruments and related assays are performing at its best.
Flow cytometry can differentiate cells based on a variety of features including size, granularity, specific surface markers or internal proteins, and DNA composition or expression. The range of topics that can be studied using flow cytometry continues to grow as scientists continuously find new ways to apply this technology in both clinical studies and basic science. Fluorescence, compensation and cellular controls are the backbone of generating reliable flow cytometry data.
The breakthrough technology creates synthetic cells that match the optical, fluorescence and biochemical features of any cell type, even rare disease types. FlowCytes®—the backbone of our products—are a series of synthetic cells assembled in a 3-D spherical matrix, physically resembling a cell. FlowCytes are nearly indistinguishable between live cells when analyzed in a flow cytometer. This makes FlowCytes the ideal cell controls to calibrate, standardize and ensure performance for instruments and assays.
Advantages of Slingshot
The innovative technology from Slingshot Biosciences is designed to help researchers get customizable cellular controls quickly, without sourcing primary cells or generating cell banks.
Even the rarest of diseases can accurately be profiled with an off-of-the-shelf control product.
- Our manufacturing process effectively eliminates lot-to-lot variability and saves time and money in qualifying QC material.
- Our non-bio based synthetic controls are stable, sustainable, and precisely mimic cell attributes.
- Compensation controls designed for spectral flow analysis with cell-like autofluorescence for superior signal-to-noise performance.
- Our synthetic cells can be customized with biomarkers, in addition, to quantitatively modified with encapsulated nucleic acids.
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