Slingshot Biosciences, Inc. has patented a scalable platform to synthesize and manufacture "synthetic cells" that match the optical, biochemical, and physical features of virtually any cell type, in a shelf-stable, non-biohazardous and convenient product.
Our synthetic cell technology is centered on the development of hydrogel spheroid microstructures. Together with an extensive synthesis library, combinatorial chemistry, and high precision manufacturing, we offer cutting edge innovation in micro and nano particle applications. As a result, we have built products that solve unmet biotechnology and healthcare challenges in the field of cell analysis, blood diagnostics, and cell therapies. Moreover, our technology can accelerate the development of surrogate controls to any cell type (days vs. years for typical cell-based products).
In contrast to traditional products (polystyrene-based and silica options), FlowCytes perfectly match cells (scatter, autofluorescence, modulus, binding etc.) which opens new avenues for advanced applications in engineered cell therapies, general cell-calibration standards (such as blood typing), and beyond.
The result is a first-of-its-kind product that allows for single-step instrument calibration, assay controls, and diagnosis without the biohazard burden of biological controls and while preserving valuable biospecimens.
Synthetic cells that can match the scatter, fluorescence, and density properties of real cells such as PBMCs (peripheral blood mononuclear cells). Achieve newfound accuracy in calibrating instruments, assays, and cell engineering.
FlowCytes exhibit autofluorescence that matches real cells, particularly with violet spectrum dyes. This feature enables a more accurate simulation of cell staining.
Match the scattering properties to virtually any cell types, even to rare malignancies and non-commercially viable controls. Development can be accomplished in weeks versus years for traditional cell line engineering.
FlowCytes are engineered to enable multiplexing of fluorophores, antibodies, proteins, and DNA/RNA. This modular platform vastly expands the applications of the technology.